association of ptpn22 rs2476601 polymorphism with rheumatoid arthritis and celiac disease in khuzestan province, southwestern iran

نویسندگان

zahra abbasi department of genetics, faculty of science, shahid chamran university of ahvaz, ahvaz, iran

seyed reza kazemi nezhad department of genetics, faculty of science, shahid chamran university of ahvaz, ahvaz, iran

mahdi pourmahdi-broojeni department of food hygiene, faculty of veterinary medicine, shahid chamran university of ahvaz, iran

elham rajaei department of internal medicine, school of medicine, ahvaz jundishapur university of medical sciences, ahvaz, iran

چکیده

background: single-nucleotide polymorphism (snp) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (ptpn22) has been shown to be a risk factor for different autoimmune diseases. this study explored the association of 1858 c/t snp with rheumatoid arthritis (ra) and celiac disease (cd) in a region covering south-west of iran. methods: totally, 52 patients with cd, 120 patients with ra and 120 healthy subjects were selected. the samples were genotyped for the rs2476601 in ptpn22 gene using the tetra-amplification refractory mutation system polymerase chain reaction. results: the frequency of +1858t risk allele was significantly increased in both ra (p=0.021, or=2.56, 95%ci=1.19-5.47) and cd (p=0.002, or=3.87, 95%ci=1.68-8.95) patients, as compared to the control group. however, no association was found between the +1858c/t ptpn22 gene snp and the anti-cyclic citrullinated peptide and rheumatoid factor positivity in ra patients. conclusions: ptpn22 gene could play a crucial role in people’s susceptibility to some autoimmune diseases.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran

Background: Single-nucleotide polymorphism (SNP) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (PTPN22) has been shown to be a risk factor for different autoimmune diseases. This study explored the association of 1858 C/T SNP with rheumatoid arthritis (RA) and celiac disease (CD) in a region covering south-west of Iran. Methods: Totally, 52 patients with CD, 120 patien...

متن کامل

Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran

BACKGROUND Single-nucleotide polymorphism (SNP) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (PTPN22) has been shown to be a risk factor for different autoimmune diseases. This study explored the association of 1858 C/T SNP with rheumatoid arthritis (RA) and celiac disease (CD) in a region covering south-west of Iran. METHODS Totally, 52 patients with CD, 120 patien...

متن کامل

Lack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran

Background and objectives: Rheumatoid arthritis (RA) is an autoimmune disease with a complex genetic background. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of T cell response. Several studies have assessed the association between PTPN22 single nucleotide polymorphisms (SNPs) with RA ...

متن کامل

association of the mthfr c677t polymorphism (rs1801133) with risk of rheumatoid arthritis in the khuzestan province of iran

conclusions our findings suggest that there is an association between the mthfr c677t polymorphism and susceptibility for the development of ra. results our results showed significant differences between the groups with respect to mthfr c677t genotype (p = 0.015) and allele frequencies (0.004). statistical analysis showed that there is no relation between gender, age, and ra risk. however, we fo...

متن کامل

Epidemiologic and Demographic Survey of Celiac Disease in Khuzestan Province

BACKGROUND Celiac disease presents with a wide spectrum of symptoms. This study clarifies different aspects of celiac disease along with the most common patterns of celiac presentation in Khuzestan Province, Iran. METHODS Patients' information was obtained by evaluation of their files from the archives of the Khuzestan Celiac Society and records at gastroenterologists' offices in this province....

متن کامل

Association of juvenile idiopathic arthritis with PTPN22 rs2476601 is specific to females in a Greek population

BACKGROUND Juvenile idiopathic arthritis (JIA) is an autoimmune disease characterized by persistent chronic arthritis. Disease risk is believed to be influenced by both genetic and environmental factors. It is well established that the PTPN22 single nucleotide polymorphism (SNP) rs2476601 is associated with JIA susceptibility. It was recently reported in an Australian study that this associatio...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian biomedical journal

جلد ۲۱، شماره ۱، صفحات ۶۱-۶۶

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023